Science Daily 2/24/2020
The collaborative research, which involved scientists from Trinity College Dublin and the University of Maryland School of Medicine, Baltimore, USA, also suggests that the impact of TBI on brain degeneration may be modifiable a relatively long time after the injury was sustained — something at odds with current thinking.
Triggered by trauma, microglia — the brain’s immune cells — morph into an inflammatory state, which helps to protect the brain. However, long-term inflammation after TBI may contribute to neurological degeneration and cognitive declines similar to those observed in TBI-associated neurodegenerative diseases, such as chronic traumatic encephalopathy and Alzheimer’s disease.
Full Article: Resetting immune cells improves traumatic brain injury recovery in preclinical trials